Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity

The ability of the human immune system to respond to vaccination declines with age. We identified an age-associated defect in T cell receptor (TCR)-induced ERK phosphorylation in naïve CD4(+) T cells (P<0.0001) while other signals, such as ZAP70 and PLC-γ1 phosphorylation were not impaired. The d...

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Detalles Bibliográficos
Autores principales: Li, Guangjin, Yu, Mingcan, Lee, Won-Woo, Tsang, Michael, Krishnan, Eswar, Weyand, Cornelia M., Goronzy, Jörg J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466346/
https://www.ncbi.nlm.nih.gov/pubmed/23023500
http://dx.doi.org/10.1038/nm.2963

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466346/
https://www.ncbi.nlm.nih.gov/pubmed/23023500
http://dx.doi.org/10.1038/nm.2963

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