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Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity
The ability of the human immune system to respond to vaccination declines with age. We identified an age-associated defect in T cell receptor (TCR)-induced ERK phosphorylation in naïve CD4(+) T cells (P<0.0001) while other signals, such as ZAP70 and PLC-γ1 phosphorylation were not impaired. The d...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466346/ https://www.ncbi.nlm.nih.gov/pubmed/23023500 http://dx.doi.org/10.1038/nm.2963 |