Repair of cisplatin-induced DNA interstrand crosslinks by a replication-independent pathway involving transcription-coupled repair and translesion synthesis

DNA interstrand crosslinks (ICLs) formed by antitumor agents, such as cisplatin or mitomycin C, are highly cytotoxic DNA lesions. Their repair is believed to be triggered primarily by the stalling of replication forks at ICLs in S-phase. There is, however, increasing evidence that ICL repair can als...

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Detalles Bibliográficos
Autores principales: Enoiu, Milica, Jiricny, Josef, Schärer, Orlando D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467066/
https://www.ncbi.nlm.nih.gov/pubmed/22810206
http://dx.doi.org/10.1093/nar/gks670

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467066/
https://www.ncbi.nlm.nih.gov/pubmed/22810206
http://dx.doi.org/10.1093/nar/gks670

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