PKC phosphorylates HEXIM1 and regulates P-TEFb activity

The positive transcription elongation factor b (P-TEFb) regulates RNA polymerase II elongation. In cells, P-TEFb partitions between small active and larger inactive states. In the latter, HEXIM1 binds to 7SK snRNA and recruits as well as inactivates P-TEFb in the 7SK snRNP. Several stimuli can affec...

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Detalles Bibliográficos
Autores principales: Fujinaga, Koh, Barboric, Matjaz, Li, Qintong, Luo, Zeping, Price, David H., Peterlin, B. Matija
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467075/
https://www.ncbi.nlm.nih.gov/pubmed/22821562
http://dx.doi.org/10.1093/nar/gks682

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467075/
https://www.ncbi.nlm.nih.gov/pubmed/22821562
http://dx.doi.org/10.1093/nar/gks682

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