Protein kinase CK2 inactivates PRH/Hhex using multiple mechanisms to de-repress VEGF-signalling genes and promote cell survival

Protein kinase CK2 promotes cell survival and the activity of this kinase is elevated in several cancers including chronic myeloid leukaemia. We have shown previously that phosphorylation of the Proline-Rich Homeodomain protein (PRH/Hhex) by CK2 inhibits the DNA-binding activity of this transcriptio...

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Detalles Bibliográficos
Autores principales: Noy, Peter, Sawasdichai, Anyaporn, Jayaraman, Padma-Sheela, Gaston, Kevin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467080/
https://www.ncbi.nlm.nih.gov/pubmed/22844093
http://dx.doi.org/10.1093/nar/gks687

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467080/
https://www.ncbi.nlm.nih.gov/pubmed/22844093
http://dx.doi.org/10.1093/nar/gks687

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