Brimonidine Blocks Glutamate Excitotoxicity-Induced Oxidative Stress and Preserves Mitochondrial Transcription Factor A in Ischemic Retinal Injury

Glutamate excitotoxicity-induced oxidative stress have been linked to mitochondrial dysfunction in retinal ischemia and optic neuropathies including glaucoma. Brimonindine (BMD), an alpha 2-adrenergic receptor agonist, contributes to the neuroprotection of retinal ganglion cells (RGCs) against gluta...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Dongwook, Kim, Keun-Young, Noh, You Hyun, Chai, Stephen, Lindsey, James D., Ellisman, Mark H., Weinreb, Robert N., Ju, Won-Kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467218/
https://www.ncbi.nlm.nih.gov/pubmed/23056591
http://dx.doi.org/10.1371/journal.pone.0047098

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467218/
https://www.ncbi.nlm.nih.gov/pubmed/23056591
http://dx.doi.org/10.1371/journal.pone.0047098

Ejemplares similares