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Brimonidine Blocks Glutamate Excitotoxicity-Induced Oxidative Stress and Preserves Mitochondrial Transcription Factor A in Ischemic Retinal Injury

Glutamate excitotoxicity-induced oxidative stress have been linked to mitochondrial dysfunction in retinal ischemia and optic neuropathies including glaucoma. Brimonindine (BMD), an alpha 2-adrenergic receptor agonist, contributes to the neuroprotection of retinal ganglion cells (RGCs) against gluta...

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Detalles Bibliográficos
Autores principales:	Lee, Dongwook, Kim, Keun-Young, Noh, You Hyun, Chai, Stephen, Lindsey, James D., Ellisman, Mark H., Weinreb, Robert N., Ju, Won-Kyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467218/ https://www.ncbi.nlm.nih.gov/pubmed/23056591 http://dx.doi.org/10.1371/journal.pone.0047098

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