Efficiency of Immunotoxin Cytotoxicity Is Modulated by the Intracellular Itinerary

Pseudomonas exotoxin-based immunotoxins, including LMB-2 (antiTac(F(v))-PE38), are proposed to traffic to the trans-Golgi network (TGN) and move by a retrograde pathway to the endoplasmic reticulum, where they undergo translocation to the cytoplasm, a step that is essential for cytotoxicity. The ret...

Descripción completa

Detalles Bibliográficos
Autores principales: Tortorella, Lori L., Pipalia, Nina H., Mukherjee, Sushmita, Pastan, Ira, Fitzgerald, David, Maxfield, Frederick R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467225/
https://www.ncbi.nlm.nih.gov/pubmed/23056628
http://dx.doi.org/10.1371/journal.pone.0047320

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467225/
https://www.ncbi.nlm.nih.gov/pubmed/23056628
http://dx.doi.org/10.1371/journal.pone.0047320

Ejemplares similares