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Efficiency of Immunotoxin Cytotoxicity Is Modulated by the Intracellular Itinerary
Pseudomonas exotoxin-based immunotoxins, including LMB-2 (antiTac(F(v))-PE38), are proposed to traffic to the trans-Golgi network (TGN) and move by a retrograde pathway to the endoplasmic reticulum, where they undergo translocation to the cytoplasm, a step that is essential for cytotoxicity. The ret...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467225/ https://www.ncbi.nlm.nih.gov/pubmed/23056628 http://dx.doi.org/10.1371/journal.pone.0047320 |