Hypothalamic mTOR Signaling Mediates the Orexigenic Action of Ghrelin

Current evidence suggests that ghrelin, a stomach derived peptide, exerts its orexigenic action through specific modulation of Sirtuin1 (SIRT1)/p53 and AMP-activated protein kinase (AMPK) pathways, which ultimately increase the expression of agouti-related protein (AgRP) and neuropeptide Y (NPY) in...

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Detalles Bibliográficos
Autores principales: Martins, Luís, Fernández-Mallo, Diana, Novelle, Marta G., Vázquez, María J., Tena-Sempere, Manuel, Nogueiras, Rubén, López, Miguel, Diéguez, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467268/
https://www.ncbi.nlm.nih.gov/pubmed/23056530
http://dx.doi.org/10.1371/journal.pone.0046923

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467268/
https://www.ncbi.nlm.nih.gov/pubmed/23056530
http://dx.doi.org/10.1371/journal.pone.0046923

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