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Hypothalamic mTOR Signaling Mediates the Orexigenic Action of Ghrelin

Current evidence suggests that ghrelin, a stomach derived peptide, exerts its orexigenic action through specific modulation of Sirtuin1 (SIRT1)/p53 and AMP-activated protein kinase (AMPK) pathways, which ultimately increase the expression of agouti-related protein (AgRP) and neuropeptide Y (NPY) in...

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Detalles Bibliográficos
Autores principales:	Martins, Luís, Fernández-Mallo, Diana, Novelle, Marta G., Vázquez, María J., Tena-Sempere, Manuel, Nogueiras, Rubén, López, Miguel, Diéguez, Carlos
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467268/ https://www.ncbi.nlm.nih.gov/pubmed/23056530 http://dx.doi.org/10.1371/journal.pone.0046923

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