Direct Assessment of the Effect of the Gly380Arg Achondroplasia Mutation on FGFR3 Dimerization Using Quantitative Imaging FRET

The Gly380Arg mutation in FGFR3 is the genetic cause for achondroplasia (ACH), the most common form of human dwarfism. The mutation has been proposed to increase FGFR3 dimerization, but the dimerization propensities of wild-type and mutant FGFR3 have not been compared. Here we use quantitative imagi...

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Detalles Bibliográficos
Autores principales: Placone, Jesse, Hristova, Kalina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467271/
https://www.ncbi.nlm.nih.gov/pubmed/23056398
http://dx.doi.org/10.1371/journal.pone.0046678

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467271/
https://www.ncbi.nlm.nih.gov/pubmed/23056398
http://dx.doi.org/10.1371/journal.pone.0046678

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