Preparation and optimization of microemulsion of rosuvastatin calcium

Due to very less bioavailability (20%) of Rosuvastatin calcium, an attempt was made to develop and optimize microemulsion formulation. Capmul MCM, Tween 20 and PEG 400 were selected as oil, surfactant and cosurfactant respectively as the drug is having higher solubility in them. 3:1% w/w S:CoS was s...

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Autores principales: Patel, Zalak B., Patel, Kruti S., Shah, Ankit S., Surti, Naazneen I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Original/Brief
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467806/
https://www.ncbi.nlm.nih.gov/pubmed/23066186
http://dx.doi.org/10.4103/0975-7406.94164
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author Patel, Zalak B.
Patel, Kruti S.
Shah, Ankit S.
Surti, Naazneen I.
author_facet Patel, Zalak B.
Patel, Kruti S.
Shah, Ankit S.
Surti, Naazneen I.
author_sort Patel, Zalak B.
collection PubMed
description Due to very less bioavailability (20%) of Rosuvastatin calcium, an attempt was made to develop and optimize microemulsion formulation. Capmul MCM, Tween 20 and PEG 400 were selected as oil, surfactant and cosurfactant respectively as the drug is having higher solubility in them. 3:1% w/w S:CoS was selected as it gave higher microemulsion area. Optimized batch (ME-1) was selected having 5% Capmul MCM, 50% Tween 20:PEG 400 and 45% water based on evaluation parameters globule size, zeta potential, PDI, % transmittance.
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spelling pubmed-34678062012-10-12 Preparation and optimization of microemulsion of rosuvastatin calcium Patel, Zalak B. Patel, Kruti S. Shah, Ankit S. Surti, Naazneen I. J Pharm Bioallied Sci Original/Brief Due to very less bioavailability (20%) of Rosuvastatin calcium, an attempt was made to develop and optimize microemulsion formulation. Capmul MCM, Tween 20 and PEG 400 were selected as oil, surfactant and cosurfactant respectively as the drug is having higher solubility in them. 3:1% w/w S:CoS was selected as it gave higher microemulsion area. Optimized batch (ME-1) was selected having 5% Capmul MCM, 50% Tween 20:PEG 400 and 45% water based on evaluation parameters globule size, zeta potential, PDI, % transmittance. Medknow Publications & Media Pvt Ltd 2012-03 /pmc/articles/PMC3467806/ /pubmed/23066186 http://dx.doi.org/10.4103/0975-7406.94164 Text en Copyright: © Journal of Pharmacy and Bioallied Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original/Brief
Patel, Zalak B.
Patel, Kruti S.
Shah, Ankit S.
Surti, Naazneen I.
Preparation and optimization of microemulsion of rosuvastatin calcium
title Preparation and optimization of microemulsion of rosuvastatin calcium
title_full Preparation and optimization of microemulsion of rosuvastatin calcium
title_fullStr Preparation and optimization of microemulsion of rosuvastatin calcium
title_full_unstemmed Preparation and optimization of microemulsion of rosuvastatin calcium
title_short Preparation and optimization of microemulsion of rosuvastatin calcium
title_sort preparation and optimization of microemulsion of rosuvastatin calcium
topic Original/Brief
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467806/
https://www.ncbi.nlm.nih.gov/pubmed/23066186
http://dx.doi.org/10.4103/0975-7406.94164
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