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Pharmacodynamic analysis of tumour perfusion assessed by (15)O-water-PET imaging during treatment with sunitinib malate in patients with advanced malignancies

BACKGROUND: We evaluated pharmacodynamic changes in tumour perfusion using positron emission tomography (PET) imaging with (15)O-water to assess biological response to sunitinib, a multitargeted tyrosine kinase inhibitor. METHODS: Patients with advanced malignancies received sunitinib 50 mg/day oral...

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Detalles Bibliográficos
Autores principales:	Scott, Andrew M, Mitchell, Paul L, O'Keefe, Graeme, Saunder, Timothy, Hicks, Rodney J, Poon, Aurora, Baum, Charles, Brega, Nicoletta, McCarthy, Timothy J, Toner, Guy C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer 2012
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468361/ https://www.ncbi.nlm.nih.gov/pubmed/22682364 http://dx.doi.org/10.1186/2191-219X-2-31

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