Quantitative connection between polyglutamine aggregation kinetics and neurodegenerative process in patients with Huntington’s disease

BACKGROUND: Despite enormous progress in elucidating the biophysics of aggregation, no cause-and-effect relationship between protein aggregation and neurodegenerative disease has been unequivocally established. Here, we derived several risk-based stochastic kinetic models that assess genotype/phenot...

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Detalles Bibliográficos
Autores principales: Sugaya, Keizo, Matsubara, Shiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468392/
https://www.ncbi.nlm.nih.gov/pubmed/22583646
http://dx.doi.org/10.1186/1750-1326-7-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468392/
https://www.ncbi.nlm.nih.gov/pubmed/22583646
http://dx.doi.org/10.1186/1750-1326-7-20

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