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Quantitative connection between polyglutamine aggregation kinetics and neurodegenerative process in patients with Huntington’s disease
BACKGROUND: Despite enormous progress in elucidating the biophysics of aggregation, no cause-and-effect relationship between protein aggregation and neurodegenerative disease has been unequivocally established. Here, we derived several risk-based stochastic kinetic models that assess genotype/phenot...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468392/ https://www.ncbi.nlm.nih.gov/pubmed/22583646 http://dx.doi.org/10.1186/1750-1326-7-20 |