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Pharmacokinetic profiles of artesunate following multiple intravenous doses of 2, 4, and 8 mg/kg in healthy volunteers: Phase 1b study

BACKGROUND: Severe malaria results in over a million deaths every year, most of them in children aged less than five years and living in sub-Saharan Africa. Injectable artesunate (AS) was recommended as initial treatment for severe malaria by WHO in 2006. The Walter Reed Army Institute of Research (...

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Detalles Bibliográficos
Autores principales: Miller, Robert Scott, Li, Qigui, Cantilena, Louis R, Leary, Kevin J, Saviolakis, George A, Melendez, Victor, Smith, Bryan, Weina, Peter J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468400/
https://www.ncbi.nlm.nih.gov/pubmed/22853818
http://dx.doi.org/10.1186/1475-2875-11-255