Integrative Structural Modelling of the Cardiac Thin Filament: Energetics at the Interface and Conservation Patterns Reveal a Spotlight on Period 2 of Tropomyosin

Cardiomyopathies are a major health problem, with inherited cardiomyopathies, many of which are caused by mutations in genes encoding sarcomeric proteins, constituting an ever-increasing fraction of cases. To begin to study the mechanisms by which these mutations cause disease, we have employed an i...

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Detalles Bibliográficos
Autores principales: Margaret Sunitha, S, Mercer, John A., Spudich, James A., Sowdhamini, Ramanathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2012
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468436/
https://www.ncbi.nlm.nih.gov/pubmed/23071391
http://dx.doi.org/10.4137/BBI.S9798

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468436/
https://www.ncbi.nlm.nih.gov/pubmed/23071391
http://dx.doi.org/10.4137/BBI.S9798

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