Experimental and In Silico Modelling Analyses of the Gene Expression Pathway for Recombinant Antibody and By-Product Production in NS0 Cell Lines

Monoclonal antibodies are commercially important, high value biotherapeutic drugs used in the treatment of a variety of diseases. These complex molecules consist of two heavy chain and two light chain polypeptides covalently linked by disulphide bonds. They are usually expressed as recombinant prote...

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Detalles Bibliográficos
Autores principales: Mead, Emma J., Chiverton, Lesley M., Spurgeon, Sarah K., Martin, Elaine B., Montague, Gary A., Smales, C. Mark, von der Haar, Tobias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468484/
https://www.ncbi.nlm.nih.gov/pubmed/23071804
http://dx.doi.org/10.1371/journal.pone.0047422

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468484/
https://www.ncbi.nlm.nih.gov/pubmed/23071804
http://dx.doi.org/10.1371/journal.pone.0047422

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