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NF-Y Recruits Both Transcription Activator and Repressor to Modulate Tissue- and Developmental Stage-Specific Expression of Human γ-Globin Gene
The human embryonic, fetal and adult β-like globin genes provide a paradigm for tissue- and developmental stage-specific gene regulation. The fetal γ-globin gene is expressed in fetal erythroid cells but is repressed in adult erythroid cells. The molecular mechanism underlying this transcriptional s...
Autores principales: | Zhu, Xingguo, Wang, Yongchao, Pi, Wenhu, Liu, Hui, Wickrema, Amittha, Tuan, Dorothy |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468502/ https://www.ncbi.nlm.nih.gov/pubmed/23071749 http://dx.doi.org/10.1371/journal.pone.0047175 |
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