The Pro Allele of the p53 Codon 72 Polymorphism Is Associated with Decreased Intratumoral Expression of BAX and p21, and Increased Breast Cancer Risk

BACKGROUND: The TP53 Arg72Pro polymorphism encodes two p53 variants with different biochemical properties. Here we investigated the impact of this polymorphism on the expression of key p53 target genes in a panel of human breast carcinomas, breast cancer risk, and age at onset. METHODOLOGY/PRINCIPAL...

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Detalles Bibliográficos
Autores principales: Proestling, Katharina, Hebar, Alexandra, Pruckner, Nina, Marton, Erika, Vinatzer, Ursula, Schreiber, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468577/
https://www.ncbi.nlm.nih.gov/pubmed/23071787
http://dx.doi.org/10.1371/journal.pone.0047325

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468577/
https://www.ncbi.nlm.nih.gov/pubmed/23071787
http://dx.doi.org/10.1371/journal.pone.0047325

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