Rho-independent stimulation of axon outgrowth and activation of the ERK and Akt signaling pathways by C3 transferase in sensory neurons

Peripheral nerve injury triggers the activation of RhoA in spinal motor and peripheral sensory neurons. RhoA activates a number of effector proteins including the Rho-associated kinase, ROCK, which targets the cytoskeleton and leads to inhibition of neurite outgrowth. Blockade of the Rho/ROCK pathwa...

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Detalles Bibliográficos
Autores principales: Auer, Maria, Schweigreiter, Rüdiger, Hausott, Barbara, Thongrong, Sitthisak, Höltje, Markus, Just, Ingo, Bandtlow, Christine, Klimaschewski, Lars
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2012
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468917/
https://www.ncbi.nlm.nih.gov/pubmed/23087613
http://dx.doi.org/10.3389/fncel.2012.00043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468917/
https://www.ncbi.nlm.nih.gov/pubmed/23087613
http://dx.doi.org/10.3389/fncel.2012.00043

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