Degradable copolymer based on amphiphilic N-octyl-N-quatenary chitosan and low-molecular weight polyethylenimine for gene delivery

BACKGROUND: Chitosan shows particularly high biocompatibility and fairly low cytotoxicity. However, chitosan is insoluble at physiological pH. Moreover, it lacks charge, so shows poor transfection. In order to develop a new type of gene vector with high transfection efficiency and low cytotoxicity,...

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Detalles Bibliográficos
Autores principales: Liu, Chengchu, Zhu, Qing, Wu, Wenhui, Xu, Xiaolin, Wang, Xiaoyu, Gao, Shen, Liu, Kehai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2012
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469101/
https://www.ncbi.nlm.nih.gov/pubmed/23071395
http://dx.doi.org/10.2147/IJN.S36179

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469101/
https://www.ncbi.nlm.nih.gov/pubmed/23071395
http://dx.doi.org/10.2147/IJN.S36179

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