Celiac disease T-cell epitopes from gamma-gliadins: immunoreactivity depends on the genome of origin, transcript frequency, and flanking protein variation

BACKGROUND: Celiac disease (CD) is caused by an uncontrolled immune response to gluten, a heterogeneous mixture of wheat storage proteins. The CD-toxicity of these proteins and their derived peptides is depending on the presence of specific T-cell epitopes (9-mer peptides; CD epitopes) that mediate...

Descripción completa

Detalles Bibliográficos
Autores principales: Salentijn, Elma MJ, Mitea, D Cristina, Goryunova, Svetlana V, van der Meer, Ingrid M, Padioleau, Ismael, Gilissen, Luud JWJ, Koning, Frits, Smulders, Marinus JM
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469346/
https://www.ncbi.nlm.nih.gov/pubmed/22726570
http://dx.doi.org/10.1186/1471-2164-13-277

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469346/
https://www.ncbi.nlm.nih.gov/pubmed/22726570
http://dx.doi.org/10.1186/1471-2164-13-277

Ejemplares similares