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Harnessing the power of transposon mutagenesis for antibacterial target identification and evaluation

Determining the mechanism of action of bacterial growth inhibitors can be a formidable challenge in the progression of small molecules into antibacterial therapies. To help address this bottleneck, we have developed a robust transposon mutagenesis system using a suite of outward facing promoters in...

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Detalles Bibliográficos
Autores principales: Meredith, Timothy C., Wang, Hao, Beaulieu, Patrick, Gründling, Angelika, Roemer, Terry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469428/
https://www.ncbi.nlm.nih.gov/pubmed/23094235
http://dx.doi.org/10.4161/mge.21647