Cdon Mutation and Fetal Ethanol Exposure Synergize to Produce Midline Signaling Defects and Holoprosencephaly Spectrum Disorders in Mice

Holoprosencephaly (HPE) is a remarkably common congenital anomaly characterized by failure to define the midline of the forebrain and midface. HPE is associated with heterozygous mutations in Sonic hedgehog (SHH) pathway components, but clinical presentation is extremely variable and many mutation c...

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Detalles Bibliográficos
Autores principales: Hong, Mingi, Krauss, Robert S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469434/
https://www.ncbi.nlm.nih.gov/pubmed/23071453
http://dx.doi.org/10.1371/journal.pgen.1002999

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469434/
https://www.ncbi.nlm.nih.gov/pubmed/23071453
http://dx.doi.org/10.1371/journal.pgen.1002999

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