Impact of Amino Acid Substitutions in B Subunit of DNA Gyrase in Mycobacterium leprae on Fluoroquinolone Resistance

BACKGROUND: Ofloxacin is a fluoroquinolone (FQ) used for the treatment of leprosy. FQs are known to interact with both A and B subunits of DNA gyrase and inhibit supercoiling activity of this enzyme. Mutations conferring FQ resistance have been reported to be found only in the gene encoding A subuni...

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Detalles Bibliográficos
Autores principales: Yokoyama, Kazumasa, Kim, Hyun, Mukai, Tetsu, Matsuoka, Masanori, Nakajima, Chie, Suzuki, Yasuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469482/
https://www.ncbi.nlm.nih.gov/pubmed/23071850
http://dx.doi.org/10.1371/journal.pntd.0001838

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469482/
https://www.ncbi.nlm.nih.gov/pubmed/23071850
http://dx.doi.org/10.1371/journal.pntd.0001838

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