Cargando…

Impact of Amino Acid Substitutions in B Subunit of DNA Gyrase in Mycobacterium leprae on Fluoroquinolone Resistance

BACKGROUND: Ofloxacin is a fluoroquinolone (FQ) used for the treatment of leprosy. FQs are known to interact with both A and B subunits of DNA gyrase and inhibit supercoiling activity of this enzyme. Mutations conferring FQ resistance have been reported to be found only in the gene encoding A subuni...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yokoyama, Kazumasa, Kim, Hyun, Mukai, Tetsu, Matsuoka, Masanori, Nakajima, Chie, Suzuki, Yasuhiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469482/ https://www.ncbi.nlm.nih.gov/pubmed/23071850 http://dx.doi.org/10.1371/journal.pntd.0001838

Ejemplares similares

DC-159a Shows Inhibitory Activity against DNA Gyrases of Mycobacterium leprae
por: Yamaguchi, Tomoyuki, et al.
Publicado: (2016)

DNA gyrase could be a crucial regulatory factor for growth and survival of Mycobacterium leprae
por: Kim, Hyun, et al.
Publicado: (2019)

Characterization of DNA Gyrase Activity and Elucidation of the Impact of Amino Acid Substitution in GyrA on Fluoroquinolone Resistance in Mycobacterium avium
por: Thapa, Jeewan, et al.
Publicado: (2023)

Profiling of Intracellular Metabolites: An Approach to Understanding the Characteristic Physiology of Mycobacterium leprae
por: Miyamoto, Yuji, et al.
Publicado: (2016)

A Lipopeptide Facilitate Induction of Mycobacterium leprae Killing in Host Cells
por: Maeda, Yumi, et al.
Publicado: (2011)

Molecular Characterization of Mycobacterium ulcerans DNA Gyrase and Identification of Mutations Reducing Susceptibility to Quinolones In Vitro
por: Kim, Hyun, et al.
Publicado: (2022)

Suppression of gyrase-mediated resistance by C7 aryl fluoroquinolones
por: Malik, Muhammad, et al.
Publicado: (2016)

Pathogenicity and virulence of Mycobacterium leprae
por: Sugawara-Mikami, Mariko, et al.
Publicado: (2022)

Spiropyrimidinetriones: a Class of DNA Gyrase Inhibitors with Activity against Mycobacterium tuberculosis and without Cross-Resistance to Fluoroquinolones
por: Basarab, Gregory S., et al.
Publicado: (2022)

Lepra Bubalorum, a Potential Reservoir of Mycobacterium leprae
por: Faber, William R., et al.
Publicado: (2021)

Mycobacterium fluoroquinolone resistance protein B, a novel small GTPase, is involved in the regulation of DNA gyrase and drug resistance
por: Tao, Jun, et al.
Publicado: (2013)

Mycobacterium leprae in bone marrow
por: de Oliveira, Leonardo Rodrigues, et al.
Publicado: (2014)

Sensitivity of Mycobacterium leprae to Telacebec
por: Lahiri, Ramanuj, et al.
Publicado: (2022)

Role of Subunit Exchange and Electrostatic Interactions on the Chaperone Activity of Mycobacterium leprae HSP18
por: Nandi, Sandip Kumar, et al.
Publicado: (2015)

Phylogenomics and antimicrobial resistance of the leprosy bacillus Mycobacterium leprae
por: Benjak, Andrej, et al.
Publicado: (2018)

Deoxynybomycins inhibit mutant DNA gyrase and rescue mice infected with fluoroquinolone-resistant bacteria
por: Parkinson, Elizabeth I., et al.
Publicado: (2015)

Lipid Droplets and Mycobacterium leprae Infection
por: Elamin, Ayssar A., et al.
Publicado: (2012)

Nitazoxanide is active against Mycobacterium leprae
por: Bailey, Mai Ann, et al.
Publicado: (2017)

The Presence of Mycobacterium leprae in Wild Rodents
por: de Lima, Maxwell Furtado, et al.
Publicado: (2022)

Recognition of DNA Supercoil Geometry by Mycobacterium tuberculosis Gyrase
por: Ashley, Rachel E., et al.
Publicado: (2017)

Localization of CORO1A in the Macrophages Containing Mycobacterium leprae
por: Suzuki, Koichi, et al.
Publicado: (2006)

The Structural Modeling of the Interaction between Levofloxacin and the Mycobacterium tuberculosis Gyrase Catalytic Site Sheds Light on the Mechanisms of Fluoroquinolones Resistant Tuberculosis in Colombian Clinical Isolates
por: Alvarez, N., et al.
Publicado: (2014)

The key DNA-binding residues in the C-terminal domain of Mycobacterium tuberculosis DNA gyrase A subunit (GyrA)
por: Huang, You-Yi, et al.
Publicado: (2006)

CELLULAR REACTIONS TO WAXES FROM MYCOBACTERIUM LEPRAE
por: Sabin, F. R., et al.
Publicado: (1935)

Mycobacterium leprae or tuberculosis: A Diagnostic Dilemma
por: Thangaraju, Pugazhenthan, et al.
Publicado: (2017)

Evolutionary history of Mycobacterium leprae in the Pacific Islands
por: Blevins, Kelly E., et al.
Publicado: (2020)

Insights into Mycobacterium leprae Proteomics and Biomarkers—An Overview
por: Gautam, Sakshi, et al.
Publicado: (2021)

Fecal Excretion of Mycobacterium leprae, Burkina Faso
por: Singh, Ajay Vir, et al.
Publicado: (2021)

Fecal Excretion of Mycobacterium leprae, Burkina Faso
por: Millogo, Anselme, et al.
Publicado: (2021)

Modulation of the Response to Mycobacterium leprae and Pathogenesis of Leprosy
por: Cabral, Natasha, et al.
Publicado: (2022)

Bypassing Fluoroquinolone Resistance with Quinazolinediones: Studies of Drug–Gyrase–DNA Complexes Having Implications for Drug Design
por: Drlica, Karl, et al.
Publicado: (2014)

Alternations in DNA gyrase genes in low-level fluoroquinolone-resistant Moraxella catarrhalis strains isolated in Poland
por: Król-Turmińska, Katarzyna, et al.
Publicado: (2018)

Targeting Bacterial Gyrase with Cystobactamid, Fluoroquinolone, and Aminocoumarin Antibiotics Induces Distinct Molecular Signatures in Pseudomonas aeruginosa
por: Franke, Raimo, et al.
Publicado: (2021)

Experimental and Molecular Docking Studies of Cyclic Diphenyl Phosphonates as DNA Gyrase Inhibitors for Fluoroquinolone-Resistant Pathogens
por: Saleh, Neveen M., et al.
Publicado: (2022)

Acquisition of fluoroquinolone resistance leads to increased biofilm formation and pathogenicity in Campylobacter jejuni
por: Whelan, Matthew V. X., et al.
Publicado: (2019)

Computational saturation mutagenesis to predict structural consequences of systematic mutations in the beta subunit of RNA polymerase in Mycobacterium leprae
por: Vedithi, Sundeep Chaitanya, et al.
Publicado: (2020)

Mycobacterium leprae genomes from naturally infected nonhuman primates
por: Honap, Tanvi P., et al.
Publicado: (2018)

The role of Ca(2+) in the activity of Mycobacterium tuberculosis DNA gyrase
por: Karkare, Shantanu, et al.
Publicado: (2012)

Piperidine-4-Carboxamides Target DNA Gyrase in Mycobacterium abscessus
por: Negatu, Dereje Abate, et al.
Publicado: (2021)

Resistance of M. leprae to Quinolones: A Question of Relativity?
por: Veziris, Nicolas, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_aujrkdvvri2pb4q8u4s4eae2tq