Severe Thymic Atrophy in a Mouse Model of Skin Inflammation Accounts for Impaired TNFR1 Signaling

Transgenic mice expressing the caspase-cleaved form of the tyrosine kinase Lyn (LynΔN) develop a TNFα-dependent skin disease that accurately recapitulates human psoriasis. Participation of lymphocytes in this disease was confirmed by backcrossing LynΔN mice on a Rag-1 deficient background. The prese...

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Detalles Bibliográficos
Autores principales: Belhacéne, Nathalie, Gamas, Parvati, Gonçalvès, Diogo, Jacquin, Marie, Beneteau, Marie, Jacquel, Arnaud, Colosetti, Pascal, Ricci, Jean-Ehrland, Wakkach, Abdellilah, Auberger, Patrick, Marchetti, Sandrine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469485/
https://www.ncbi.nlm.nih.gov/pubmed/23071785
http://dx.doi.org/10.1371/journal.pone.0047321

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469485/
https://www.ncbi.nlm.nih.gov/pubmed/23071785
http://dx.doi.org/10.1371/journal.pone.0047321

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