Matrix compliance regulates Rac1b localization, NADPH oxidase assembly, and epithelial–mesenchymal transition

Epithelial–mesenchymal transition (EMT) is a form of epithelial plasticity implicated in fibrosis and tumor metastasis. Here we show that the mechanical rigidity of the microenvironment plays a pivotal role in the promotion of EMT by controlling the subcellular localization and downstream signaling...

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Detalles Bibliográficos
Autores principales: Lee, KangAe, Chen, Qike K., Lui, Cecillia, Cichon, Magdalena A., Radisky, Derek C., Nelson, Celeste M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2012
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469523/
https://www.ncbi.nlm.nih.gov/pubmed/22918955
http://dx.doi.org/10.1091/mbc.E12-02-0166

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469523/
https://www.ncbi.nlm.nih.gov/pubmed/22918955
http://dx.doi.org/10.1091/mbc.E12-02-0166

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