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Matrix compliance regulates Rac1b localization, NADPH oxidase assembly, and epithelial–mesenchymal transition
Epithelial–mesenchymal transition (EMT) is a form of epithelial plasticity implicated in fibrosis and tumor metastasis. Here we show that the mechanical rigidity of the microenvironment plays a pivotal role in the promotion of EMT by controlling the subcellular localization and downstream signaling...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The American Society for Cell Biology
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469523/ https://www.ncbi.nlm.nih.gov/pubmed/22918955 http://dx.doi.org/10.1091/mbc.E12-02-0166 |