Macrophages Sequester Clofazimine in an Intracellular Liquid Crystal-Like Supramolecular Organization

Clofazimine is a poorly-soluble but orally-bioavailable small molecule drug that massively accumulates in macrophages when administered over prolonged periods of time. To determine whether crystal-like drug inclusions (CLDIs) that form in subcellular spaces correspond to pure clofazimine crystals, m...

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Detalles Bibliográficos
Autores principales: Baik, Jason, Rosania, Gus R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469554/
https://www.ncbi.nlm.nih.gov/pubmed/23071814
http://dx.doi.org/10.1371/journal.pone.0047494

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469554/
https://www.ncbi.nlm.nih.gov/pubmed/23071814
http://dx.doi.org/10.1371/journal.pone.0047494

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