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Macrophages Sequester Clofazimine in an Intracellular Liquid Crystal-Like Supramolecular Organization
Clofazimine is a poorly-soluble but orally-bioavailable small molecule drug that massively accumulates in macrophages when administered over prolonged periods of time. To determine whether crystal-like drug inclusions (CLDIs) that form in subcellular spaces correspond to pure clofazimine crystals, m...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469554/ https://www.ncbi.nlm.nih.gov/pubmed/23071814 http://dx.doi.org/10.1371/journal.pone.0047494 |