The Role of Chaperone-Mediated Autophagy in Huntingtin Degradation

Huntington Disease (HD) is caused by an abnormal expansion of polyQ tract in the protein named huntingtin (Htt). HD pathology is featured by accumulation and aggregation of mutant Htt in striatal and cortical neurons. Aberrant Htt degradation is implicated in HD pathogenesis. The aim of this study w...

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Detalles Bibliográficos
Autores principales: Qi, Lin, Zhang, Xing-Ding, Wu, Jun-Chao, Lin, Fang, Wang, Jin, DiFiglia, Marian, Qin, Zheng-Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469570/
https://www.ncbi.nlm.nih.gov/pubmed/23071649
http://dx.doi.org/10.1371/journal.pone.0046834

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469570/
https://www.ncbi.nlm.nih.gov/pubmed/23071649
http://dx.doi.org/10.1371/journal.pone.0046834

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