Identification of Cytoskeleton-Associated Proteins Essential for Lysosomal Stability and Survival of Human Cancer Cells

Microtubule-disturbing drugs inhibit lysosomal trafficking and induce lysosomal membrane permeabilization followed by cathepsin-dependent cell death. To identify specific trafficking-related proteins that control cell survival and lysosomal stability, we screened a molecular motor siRNA library in h...

Descripción completa

Detalles Bibliográficos
Autores principales: Groth-Pedersen, Line, Aits, Sonja, Corcelle-Termeau, Elisabeth, Petersen, Nikolaj H. T., Nylandsted, Jesper, Jäättelä, Marja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469574/
https://www.ncbi.nlm.nih.gov/pubmed/23071517
http://dx.doi.org/10.1371/journal.pone.0045381

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469574/
https://www.ncbi.nlm.nih.gov/pubmed/23071517
http://dx.doi.org/10.1371/journal.pone.0045381

Ejemplares similares