Protein Folding: Adding a Nucleus to Guide Helix Docking Reduces Landscape Roughness

The elongated three-helix‐bundle spectrin domains R16 and R17 fold and unfold unusually slowly over a rough energy landscape, in contrast to the homologue R15, which folds fast over a much smoother, more typical landscape. R15 folds via a nucleation–condensation mechanism that guides the docking of...

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Detalles Bibliográficos
Autores principales: Wensley, Beth G., Kwa, Lee Gyan, Shammas, Sarah L., Rogers, Joseph M., Clarke, Jane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469821/
https://www.ncbi.nlm.nih.gov/pubmed/22917971
http://dx.doi.org/10.1016/j.jmb.2012.08.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469821/
https://www.ncbi.nlm.nih.gov/pubmed/22917971
http://dx.doi.org/10.1016/j.jmb.2012.08.003

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