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Protein Folding: Adding a Nucleus to Guide Helix Docking Reduces Landscape Roughness
The elongated three-helix‐bundle spectrin domains R16 and R17 fold and unfold unusually slowly over a rough energy landscape, in contrast to the homologue R15, which folds fast over a much smoother, more typical landscape. R15 folds via a nucleation–condensation mechanism that guides the docking of...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3469821/ https://www.ncbi.nlm.nih.gov/pubmed/22917971 http://dx.doi.org/10.1016/j.jmb.2012.08.003 |