Molecular mechanisms of MYCN-dependent apoptosis and the MDM2–p53 pathway: an Achille’s heel to be exploited for the therapy of MYCN-amplified neuroblastoma

The p53 oncosuppressor is very seldom mutated in neuroblastoma, but several mechanisms cooperate to its functional inactivation in this tumor. Increased MDM2 levels, due to genetic amplification or constitutive inhibition of p14( ARF), significantly contribute to this event highlighting p53 reactiva...

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Detalles Bibliográficos
Autores principales: Petroni, Marialaura, Veschi, Veronica, Gulino, Alberto, Giannini, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2012
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470040/
https://www.ncbi.nlm.nih.gov/pubmed/23091802
http://dx.doi.org/10.3389/fonc.2012.00141

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470040/
https://www.ncbi.nlm.nih.gov/pubmed/23091802
http://dx.doi.org/10.3389/fonc.2012.00141

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