Mannosylated Mucin-Type Immunoglobulin Fusion Proteins Enhance Antigen-Specific Antibody and T Lymphocyte Responses

Targeting antigens to antigen-presenting cells (APC) improve their immunogenicity and capacity to induce Th1 responses and cytotoxic T lymphocytes (CTL). We have generated a mucin-type immunoglobulin fusion protein (PSGL-1/mIgG(2b)), which upon expression in the yeast Pichia pastoris became multival...

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Detalles Bibliográficos
Autores principales: Ahlén, Gustaf, Strindelius, Lena, Johansson, Tomas, Nilsson, Anki, Chatzissavidou, Nathalie, Sjöblom, Magnus, Rova, Ulrika, Holgersson, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470573/
https://www.ncbi.nlm.nih.gov/pubmed/23071675
http://dx.doi.org/10.1371/journal.pone.0046959

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470573/
https://www.ncbi.nlm.nih.gov/pubmed/23071675
http://dx.doi.org/10.1371/journal.pone.0046959

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