Non-Canonical Smads Phosphorylation Induced by the Glutamate Release Inhibitor, Riluzole, through GSK3 Activation in Melanoma

Riluzole, an inhibitor of glutamate release, has shown the ability to inhibit melanoma cell xenograft growth. A phase 0 clinical trial of riluzole as a single agent in patients with melanoma resulted in involution of tumors associated with inhibition of both the mitogen-activated protein kinase (MAP...

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Detalles Bibliográficos
Autores principales: Abushahba, Walid, Olabisi, Oyenike O., Jeong, Byeong-Seon, Boregowda, Rajeev K., Wen, Yu, Liu, Fang, Goydos, James S., Lasfar, Ahmed, Cohen-Solal, Karine A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470581/
https://www.ncbi.nlm.nih.gov/pubmed/23077590
http://dx.doi.org/10.1371/journal.pone.0047312

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470581/
https://www.ncbi.nlm.nih.gov/pubmed/23077590
http://dx.doi.org/10.1371/journal.pone.0047312

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