Reprioritizing Genetic Associations in Hit Regions Using LASSO-Based Resample Model Averaging

Significance testing one SNP at a time has proven useful for identifying genomic regions that harbor variants affecting human disease. But after an initial genome scan has identified a “hit region” of association, single-locus approaches can falter. Local linkage disequilibrium (LD) can make both th...

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Detalles Bibliográficos
Autores principales: Valdar, William, Sabourin, Jeremy, Nobel, Andrew, Holmes, Christopher C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2012
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470705/
https://www.ncbi.nlm.nih.gov/pubmed/22549815
http://dx.doi.org/10.1002/gepi.21639

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470705/
https://www.ncbi.nlm.nih.gov/pubmed/22549815
http://dx.doi.org/10.1002/gepi.21639

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