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Reprioritizing Genetic Associations in Hit Regions Using LASSO-Based Resample Model Averaging
Significance testing one SNP at a time has proven useful for identifying genomic regions that harbor variants affecting human disease. But after an initial genome scan has identified a “hit region” of association, single-locus approaches can falter. Local linkage disequilibrium (LD) can make both th...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Blackwell Publishing Ltd
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470705/ https://www.ncbi.nlm.nih.gov/pubmed/22549815 http://dx.doi.org/10.1002/gepi.21639 |