Autophagy Restricts Proliferation Driven By Oncogenic Phosphatidylinositol 3-Kinase in Three-Dimensional Culture

Autophagy is a tightly regulated lysosomal self-digestion process that can both promote and impede tumorigenesis. Here, we utilize a three-dimensional (3D) culture model to address how interactions between autophagy and the PI3K/Akt/mTOR pathway impact the malignant behavior of cells carrying a tumo...

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Detalles Bibliográficos
Autores principales: Chen, Nan, Eritja, Nuria, Lock, Rebecca, Debnath, Jayanta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470740/
https://www.ncbi.nlm.nih.gov/pubmed/22777351
http://dx.doi.org/10.1038/onc.2012.277

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470740/
https://www.ncbi.nlm.nih.gov/pubmed/22777351
http://dx.doi.org/10.1038/onc.2012.277

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