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Autophagy Restricts Proliferation Driven By Oncogenic Phosphatidylinositol 3-Kinase in Three-Dimensional Culture

Autophagy is a tightly regulated lysosomal self-digestion process that can both promote and impede tumorigenesis. Here, we utilize a three-dimensional (3D) culture model to address how interactions between autophagy and the PI3K/Akt/mTOR pathway impact the malignant behavior of cells carrying a tumo...

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Detalles Bibliográficos
Autores principales:	Chen, Nan, Eritja, Nuria, Lock, Rebecca, Debnath, Jayanta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470740/ https://www.ncbi.nlm.nih.gov/pubmed/22777351 http://dx.doi.org/10.1038/onc.2012.277

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