Cytotoxic T lymphocyte effector function is independent of nucleus–centrosome dissociation

Cytotoxic T lymphocytes (CTLs) kill tumorigenic and virally infected cells by targeted secretion of lytic granule contents. The precise point at which secretion occurs is directed by the centrosome docking at the immunological synapse (IS). The centrosome is highly dynamic in CTLs, lagging behind th...

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Detalles Bibliográficos
Autores principales: Lui-Roberts, Winnie W Y, Stinchcombe, Jane C, Ritter, Alex T, Akhmanova, Anna, Karakesisoglou, Iakowos, Griffiths, Gillian M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2012
Materias:
Molecular Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470926/
https://www.ncbi.nlm.nih.gov/pubmed/22736282
http://dx.doi.org/10.1002/eji.201242525

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470926/
https://www.ncbi.nlm.nih.gov/pubmed/22736282
http://dx.doi.org/10.1002/eji.201242525

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