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Chemical, genetic and structural assessment of pyridoxal kinase as a drug target in the African trypanosome
Pyridoxal-5′-phosphate (vitamin B(6)) is an essential cofactor for many important enzymatic reactions such as transamination and decarboxylation. African trypanosomes are unable to synthesise vitamin B(6)de novo and rely on uptake of B(6) vitamers such as pyridoxal and pyridoxamine from their hosts,...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Blackwell Publishing Ltd
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470933/ https://www.ncbi.nlm.nih.gov/pubmed/22857512 http://dx.doi.org/10.1111/j.1365-2958.2012.08189.x |