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Chemical, genetic and structural assessment of pyridoxal kinase as a drug target in the African trypanosome

Pyridoxal-5′-phosphate (vitamin B(6)) is an essential cofactor for many important enzymatic reactions such as transamination and decarboxylation. African trypanosomes are unable to synthesise vitamin B(6)de novo and rely on uptake of B(6) vitamers such as pyridoxal and pyridoxamine from their hosts,...

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Detalles Bibliográficos
Autores principales:	Jones, Deuan C, Alphey, Magnus S, Wyllie, Susan, Fairlamb, Alan H
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2012
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3470933/ https://www.ncbi.nlm.nih.gov/pubmed/22857512 http://dx.doi.org/10.1111/j.1365-2958.2012.08189.x

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