CtIP promotes microhomology-mediated alternative end-joining during class switch recombination

Immunoglobulin heavy chain (Igh) class switch recombination (CSR) requires targeted introduction of DNA double strand breaks (DSBs) into repetitive “switch” region DNA elements in the Igh locus and subsequent ligation between distal DSBs. Both canonical non-homologous end-joining (C-NHEJ) that seals...

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Detalles Bibliográficos
Autores principales: Lee-Theilen, Mieun, Matthews, Allysia J., Kelly, Dierdre, Zheng, Simin, Chaudhuri, Jayanta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471154/
https://www.ncbi.nlm.nih.gov/pubmed/21131982
http://dx.doi.org/10.1038/nsmb.1942

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471154/
https://www.ncbi.nlm.nih.gov/pubmed/21131982
http://dx.doi.org/10.1038/nsmb.1942

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