A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B

By phosphorylating Thr3 of histone H3, Haspin promotes centromeric recruitment of the chromosome passenger complex (CPC) during mitosis. Aurora B kinase, a CPC subunit, sustains chromosome bi-orientation and the spindle assembly checkpoint (SAC). Here, we characterize the small molecule 5-iodotuberc...

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Detalles Bibliográficos
Autores principales: De Antoni, Anna, Maffini, Stefano, Knapp, Stefan, Musacchio, Andrea, Santaguida, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471222/
https://www.ncbi.nlm.nih.gov/pubmed/23071153
http://dx.doi.org/10.1083/jcb.201205119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471222/
https://www.ncbi.nlm.nih.gov/pubmed/23071153
http://dx.doi.org/10.1083/jcb.201205119

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