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A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B

By phosphorylating Thr3 of histone H3, Haspin promotes centromeric recruitment of the chromosome passenger complex (CPC) during mitosis. Aurora B kinase, a CPC subunit, sustains chromosome bi-orientation and the spindle assembly checkpoint (SAC). Here, we characterize the small molecule 5-iodotuberc...

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Detalles Bibliográficos
Autores principales:	De Antoni, Anna, Maffini, Stefano, Knapp, Stefan, Musacchio, Andrea, Santaguida, Stefano
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2012
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471222/ https://www.ncbi.nlm.nih.gov/pubmed/23071153 http://dx.doi.org/10.1083/jcb.201205119

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